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4 edition of Rapid hyaluronan uptake is associated with enhanced motility and transformation found in the catalog.

Rapid hyaluronan uptake is associated with enhanced motility and transformation

Rapid hyaluronan uptake is associated with enhanced motility and transformation

implications for an intracellular mode of action.

by

  • 20 Want to read
  • 4 Currently reading

Published by National Library of Canada in Ottawa .
Written in English


Edition Notes

Thesis (M.Sc.) -- University of Toronto, 1999.

SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
FormatMicroform
Pagination2 microfiches : negative. --
ID Numbers
Open LibraryOL19925034M
ISBN 100612458776
OCLC/WorldCa47270228

  Proceedings: AACR Annual Meeting ; March April 3, ; Atlanta, GA The accumulation of hyaluronan (HA) in the solid tumor microenvironment (TME) can be associated with poor prognosis in several human cancers. Accumulation of HA in the TME can increase interstitial pressure that compresses local blood vessels and impairs the access of anti-cancer : Feng Gao, Susan Zimmerman, Kelly Chen, Daniel C. Maneval, Chunmei Zhao.   Msx1 and Msx2, which belong to the highly conserved Nk family of homeobox genes, display overlapping expression patterns and redundant functions in multiple tissues and organs during vertebrate development. Msx1 and Msx2 have well-documented roles in mediating epithelial-mesenchymal interactions during organogenesis. Given that both Msx1 and Msx2 are crucial Cited by: Elevated hyaluronan and hyaluronan-mediated motility receptor associated with biochemical failure. Ma in Publications, Prostate. Dr. Stephen Schmechel collaborated with Dr. James McCarthy at the University of Minnesota to analyze hyaluronan pathway related members in intermediate-grade prostate cancer biospecimens. They analyzed prostate cancer tissue microarrays using. The hyaluronan synthase 1 (HAS1) gene encodes a plasma membrane protein that synthesizes hyaluronan, an extracellular matrix molecule. Previously, in patients with Waldenström's macroglobulinemia (WM), we detected upregulation of HAS1 transcripts and identified aberrant splice variants of this gene. Aberrant splicing of HAS1 results from activation of cryptic splice by: 9.


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Rapid hyaluronan uptake is associated with enhanced motility and transformation Download PDF EPUB FB2

Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action. Collis L(1), Hall C, Lange L, Ziebell M, Prestwich R, Turley EA. Author information: (1)The Hospital for Sick Children, Division of Cardiovascular Research, Toronto, Ont Cited by: Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action Author links open overlay panel L Collis a C Hall b L Lange b M Ziebell c R Prestwich c E.A Turley aCited by: RAPID HYALURONAN UPTAKE IS ASSOCLATED WITH ENHANCED MOTILITY AND TRANSFORMATION: IMPLICATIONS FOR AN INTRACELLULAR MODE OF ACTION Lisa Janine Collis A thesis submitted in conformity with the requirements for the Degree Master of Science, Graduate Department of Anatorny and Ce11 Biology University of TorontoAuthor: Lisa Janine Collis.

Key words: Hyaluronan; RHAMM; CD44; Internalization; Lamella; Nucleus 1. Introduction RHAMM is an hyaladherin that occurs at several subcel-lular loci including the cell surface, cytoplasm and nucleus [1^ 3].

An intracellular as well as surface form of RHAMM reg-ulates cell motility and controls the cell cycle. TR-HA uptake is blocked by: excess polymeric HA, HA-dodecasaccharide, colchicine, BrefeldinA, and by digestion of TR-HA with hyaluronidase. Uptake is dose dependent, saturable and strongly enhanced upon cell attachment, monolayer wounding and : Lisa Janine Collis.

However, in patients who have breast and prostate carcinomas, both hyaluronan that is associated with tumour cells and stromal hyaluronan are linked with cancer progressCited by: Collis L, Hall C, Lange L, Ziebell M, Prestwich R, Turley EA: Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of Cited by: Hyaluronan (HA) is found in the extracellular matrix of many tissues where it is thought to promote cell migration and proliferation.

Recent data suggests that hyaluronan-dependent pericellular matrix formation is a rapid process which occurs as cells detach during mitosis and by: 1. Accepted on Decem ; Introduction. Hyaluronan (also called hyaluronic acid or hyaluronate) is a linear glycosaminoglycan composed of repeating disaccharides of glucuronic acid and N-acetylglucosamine:[β1,4-GlcUA-β1,3-GlcNAc-] usually contains –25, disaccharides, exhibits varying molecular weights ranging from 10 5 to 10 7 Da, and has an extended length of up to Cited by: LMW HA interactions with CD44 are associated with certain pathological conditions, including inflammation, cancer, and induction of angiogenesis (23, 33, –).

Hyaluronan chains can be organized into ECM structures by association with binding by: Hyaluronan at lower concentrations is internalized by receptor mediated uptake, but at higher concentrations in the incubation medium, fluid phase uptake also takes place. The receptor mediated uptake does not utilize coated pits or : Raija Tammi, Kirsi Rilla, Juha-Pekka Pienimäki, Michael Hogg, Donald K.

MacCallum, Vincent C. Hascal. HYALURONIC ACID HYDROGEL FILM: A NEW BIOMATERIAL FOR DRUG DELIVERY AND WOUND HEALING Yi Luo', Kelly R. Kirker", & Glenn D. Prestwich',t,2 'Department of Medicinal Chemistry, The University of Utah, 30 South East, RoomSalt Lake City, Utah USA 'Department of Bioengineering, The University of Utah, 20 South East, RoomSalt Lake City, Utah ]2 Cited by: 2.

RHAMM was originally described as a hyaluronan binding protein Rapid hyaluronan uptake is associated with enhanced motility and transformation book is present on the cell surface as well as inside the cell and that regulates cell motility and cell cycle.

It has been reported to occur as multiple protein forms, some of which are generated by alternative splicing of mRNA. RHAMM occurs in several sub-cellular : R. Harrison, F.-S. Wang, E.A. Turley. The hyaluronan receptor belongs to the polymorphic family of CD44 glycoproteins, which have been implicated in a variety of cellular functions including adhesion to hyaluronan and collagen, the binding of lymphocytes to high endothelial cells during extravasation, and conferring metastatic potential to carcinoma cells.

Here, we demonstrate that the receptor also participates in the uptake and. Here, we show that HA-promoted random motility of ras-transformed 10T1/2 (C3) fibroblasts requires activation of protein kinase C and is associated with rapid uptake of HA in a CD44 and RHAMM. 1. Introduction.

Vascular proliferative disorders such as atherosclerosis, restenosis or allograft rejection are characterized by arterial smooth muscle cells (ASMC) proliferation and migration associated with marked changes into extracellular matrix (ECM).Hyaluronan (HA) is a high molecular weight polysaccharide (–10, kDa) widely distributed in ECM of a variety of tissues including Cited by:   Collis L, Hall, C Lange L, Ziebell M, Prestwich R, Turley EA: Rapid hyaluronan uptake is associated with enhanced motility: implications for.

Hyaluronan is particularly prominent in the matrix of tissues and cells undergoing rapid proliferation, 23 including the matrix of malignancies. 24 Previously, it was shown that hyaluronidase treatment of cultured tumor cells caused eradication of hyaluronan, as well as several CD44 variant isoforms.

The current experiments confirmed that CD44s Cited by:   HA is present predominantly in the ECM, particularly in embryonic and malignant tissues. It occurs early in the ECM of the healing wound (Longaker et al., ) and whenever rapid repair and regeneration is also highly expressed in the glycocalyx, the pericellular coat that ensheathes most cells, and is particularly prominent on the apical surface of endothelial cells (Henry and Cited by:   Collis L, Hall C, Lange L, Ziebell M, Prestwich R, Turley EA.

Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of Cited by:   However, of most interest, coincident with the reduction in hyaluronan, there was a substantial decrease in cell proliferation, a decrease in cell motility and a decrease in cell invasiveness.

These data suggest that hyaluronan synthesized by HAS-2 in MG plays a crucial role in osteosarcoma cell proliferation, motility and by: Elevated Hyaluronan and Hyaluronan-Mediated Motility Receptor Are Associated With Biochemical Failure in Patients With Intermediate-Grade Prostate Tumors Article (PDF Available) in Cancer ( Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action 22 December | FEBS Letters, Vol.

No. 3 The Active Streptococcal Hyaluronan Synthases (HASs) Contain a Single HAS Monomer and Multiple Cardiolipin MoleculesCited by: The full text of this article hosted at is unavailable due to technical by: The pH-sensitive MPN corona allowed for a rapid release of DOX and effective cellular SNP uptake in the mildly acidic condition (pH ) mimicking TME, to which the hyaluronic acid was exposed to.

Among the protein-based hydrogel-forming polymers, various salts of hyaluronic acid (HA), aka hyaluronan or sodium hyaluronate, are used to prepare : Farid Menaa.

Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action. FEBS Lett. ; – Crossref Medline Google Scholar; 4 Brown JJ, Papaioannou VE. Ontogeny of hyaluronan secretion during early mouse development. Development.

; – Medline Google ScholarCited by: Hyaluronan-mediated motility receptor (HMMR), also known as RHAMM (Receptor for Hyaluronan Mediated Motility) is a protein which in humans is encoded by the HMMR gene. RHAMM recently has been also designated CD (cluster of differentiation ).Aliases: HMMR, CD, IHABP, RHAMM.

The first reported functional domains of RHAMM were its hyaluronan binding motifs present in D5, which encode sequences of basic amino acids that are also common to other intracellular hyaladherins, such as cdc37 and p 1 These domains are the sole hyaluronan-binding sites of RHAMM and are key to generating a motility signal from exogenous.

Inhyaluronan was demonstrated to bind specifically and with high affinity to intact cells (), and init was shown to enhance cell motility on two-dimensional culture surfaces where the hydrodynamic properties of hyaluronan were not necessary to open spaces for cells to move into ().These two demonstrations raised the possibility that hyaluronan had the potential to directly modify.

Knudson W. Tumor associated hyaluronan. Providing an extracellular matrix that facilitates invasion. Am J Pathol. ; – [PMC free article] Collis L, Hall C, Lange L, Ziebel M, Prestwich R, Turley EA.

Rapid hyaluronan uptake is associated with enhanced motility: implication for an intracellular mode of action. FEBS by: The maximum amount of non-freezing water, intimately associated with the hydrophilic groups of hylan, corresponds to 13 mol water per disaccharide unit of the hyaluronan chain.

Background: Hyaluronan (HA) is a non-sulfated glycosaminoglycan (GAG) that promotes motility, adhesion, and proliferation in mammalian cells, as mediated by cell-surface HA receptors. We sought to identify non-carbohydrate ligands that would bind to and activate cell-surface HA receptors.

Such analogs could have important therapeutic uses in the treatment of cancer, wound healing, and Cited by: Msx1 and Msx2 are required for endothelial-mesenchymal transformation of the atrioventricular cushions and patterning of the atrioventricular myocardium.

Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action. Disruption of hyaluronan synthase-2 abrogates normal cardiac. Hyaluronan-CD44 and hyaluronan-RHAMM (CD) interactions have been reported to result in the activation of signaling cascades that contribute to cell motility and proliferation.

Why some hyaluronan-CD44 interactions signal, some promote endocytic uptake, and others permit retention of hyaluronan on the cell surface has not yet been resolved. Hyaluronan: RHAMM mediated cell locomotion and signaling in tumorigenesis. J Neurooncol.

; – Crossref Medline Google Scholar; 3 Collis L, Hall C, Lange L, Ziebell M, Prestwich R, Turley EA. Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action.

FEBS by: (). Rapid hyaluronan uptake is associated with enhanced motility: implications for an intracellular mode of action. Regulated expression of a receptor for hyaluronan-mediated motility on human thymocytes and T cells.

().Author: Sheryl L. Gares and Linda M. Pilarski. Hyaluronan (HA) turnover can occur locally at the tissue of origin, where it is taken up by cells to be degraded, or released into the lymphatic and vascular systems, where it can be eliminated by the liver and kidneys.

Uptake of HA into cells for degradation involves receptor-mediated processes. Degradation of Hyaluronan. HA is removed from an organism by two routes, both of which require hyaluronida 1. Internalization and degradation by cells and destruction in the lyosome The hyaluronidase, Hyal-1, is responsible for the catabolism of intracellular HA and functions primarily in the lyosome.

10,20 This is the enzyme that creates angiogenic HA fragments since it cleaves. Start studying Microbiology Success Book. Learn vocabulary, terms, and more with flashcards, games, and other study tools.

Small, white with narrow zone of beta-hemolysis. Umbrella motility in semisolid media and end-over-end (tumbling) motility in a wet mount. group A associated, rapid inflammation and necrosis of skin, subcutaneous.

Isoforms. There are three mammalian hyaluronan synthases described to date - HAS1, HAS2 and of these isoforms resides at a different chromosome location and has been cloned.

Two of the main differences between the isoforms are the chain length of the hyaluronan molecules that they produce and the ease with which they can be released from the cell : BRENDA entry.Elevated hyaluronan and hyaluronan-mediated motility receptor are associated with biochemical failure in patients with intermediate-grade prostate tumors.

promoted HA uptake, and was required for a promigratory response to fragmented HA. Elevated hyaluronan and hyaluronan-mediated motility receptor are associated with biochemical Cited by: The high molecular weight glycosaminoglycan hyaluronan plays an important role in tissue remodeling during development, normal tissue homeostasis, and disease.

The interaction of hyaluronan with matrix hyaluronan-binding proteins and cell-surface hyaluronan receptors regulates many aspects of cell behavior such as cell migration, cell-cell adhesion, and cell by: